R&D AT HOUSEY PHARMA

ONCOLOGY

Cancer is a disease that results from a series of oncogenic events that culminate in irreparable genetic damage to normal cells. These events ultimately give rise to the uncontrolled, invasive cellular growth termed malignant cancer. Together with collaborators, our company has identified key target proteins that are involved both initially as well as in the later stages of growth of certain forms of human cancer. These target proteins remain functional when patients relapse after being treated with an initially effective drug regimen. Our findings suggest powerful new strategies for identifying new molecular entities that will interact with these target proteins and help to overcome the ability of advanced forms of cancer to resist effective drug treatment.

Diabetes

Diabetes is a disease that has reached epidemic proportions in the western nations of the world. It has been estimated that one of every five people born after the year 2000 will develop diabetes in their lifetime. More than 16 million Americans already suffer from this disease. Diabetes is manifest by the loss of the ability to control the amount of sugar (glucose) present in the blood.

Normal control of blood glucose is essential for good health and well-being. Blood glucose levels are maintained within certain limits as a result of the effects of a hormone called Insulin on various tissues and organs in the body. If the concentration of blood glucose strays outside of the normal limits, as it does in untreated diabetes, serious and sometimes fatal consequences can occur. Insulin is produced by specialized cells called “ß-cells” that are located in the pancreas.

There are two major subtypes of diabetes: Type I and Type II Diabetes